Retrograde Transport Pathway. The Secretory Pathway, Endocytic Pathway and Retrograde/Recycling For example, the retrograde transport of Nogo-A endosomes initiates growth cone collapse and inhibits neurite outgrowth [ 87 ]; this signaling may be essential for blocking unwanted outgrowth and branching during myelination. Initially, it was considered that mammalian retromer functions in the equivalent retrograde transport pathway, as demonstrated by retromer dependency of retrograde transport of cation-independent.
Two plausible pathways for rabies virus (RABV) retrograde transport in from www.researchgate.net
Retrograde transport is shown starting from a coated endosome, which is an intermediate in the maturation between early and late endosomes 27,28.The coated endosome is connected to a vast 'tubular. Generalised simplified retrograde routes available to ER trafficking toxins and viruses.Association of the toxin/receptor complex or virus/receptor complex with a receptor in detergent resistant membrane microdomains (DRM) facilitates uptake in caveosomes (C) or transport from early/sorting endosomes (EE/SE) to the TGN, directing a proportion of the toxin or virus away from the late endosome.
Two plausible pathways for rabies virus (RABV) retrograde transport in
Retrograde transport, in which proteins and lipids are shuttled between endosomes and biosynthetic/secretory compartments such as the Golgi apparatus, is crucial for a diverse range of cellular functions Retrograde transport is shown starting from a coated endosome, which is an intermediate in the maturation between early and late endosomes 27,28.The coated endosome is connected to a vast 'tubular. The idea that host factors might potentially shuttle these toxins into cells stimulated the search for endogenous client.
The Secretory Pathway, Endocytic Pathway and Retrograde/Recycling. Retrograde transport is shown starting from a coated endosome, which is an intermediate in the maturation between early and late endosomes 27,28.The coated endosome is connected to a vast 'tubular. Retrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (reviewed in Lord et al, 2013; Spang et al, 2013; Heffernan and Simpson, 2014).
PPT The Lysosome and Lysosomal Storage Disorders (LSD) PowerPoint. Generalised simplified retrograde routes available to ER trafficking toxins and viruses.Association of the toxin/receptor complex or virus/receptor complex with a receptor in detergent resistant membrane microdomains (DRM) facilitates uptake in caveosomes (C) or transport from early/sorting endosomes (EE/SE) to the TGN, directing a proportion of the toxin or virus away from the late endosome. The retrograde transport of membrane proteins from endosomes to the trans-Golgi network (TGN) is essential for internalization and recycling of membrane proteins which control a variety of physiological processes including (i) lysosomal biogenesis, (ii) ion and glucose transport, (iii) processing and secretion of polypeptide precursors and (iv) secretion of signaling proteins that regulate.